Sodium Hydroxide → HCID 67442775, compound

Participants

Reaction Steps

A mixture of benzyl 3-(6-chloro-3,3-dimethyl-1,2,3,4-tetrahydroquinolin-2-yl)benzoate (914 mg, 2.25 mmol) in methanol (30 mL) and aqueous sodium hydroxide solution (2 M, 17 mL, 34 mmol) was heated to reflux for 2 h. Solvent was removed under vacuum and the residue was acidified with 2N hydrochloric acid solution to pH=2. The precipitated white solid was collected to afford 539 mg of 3-(6-chloro-3,3-dimethyl-1,2,3,4-tetrahydroquinolin-2-yl)benzoic acid (yield: 76%) as a white powder.

Provenance & Evidence