HCID 67442054, compound → HCID 67441460, compound

HRID 1801380Notes

Reaction equation

HRID 1801380 reaction equation
[CH3:1][C:2]1([CH3:30])[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:12]([O:14][CH3:15])=[O:13])[CH:9]=2)[N:4]=[C:3]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([S:22]([N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)(=[O:24])=[O:23])[CH:17]=1>CO.O1CCCC1>[CH3:1][C:2]1([CH3:30])[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:12]([O:14][CH3:15])=[O:13])[CH:9]=2)[NH:4][CH:3]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([S:22]([N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)(=[O:24])=[O:23])[CH:17]=1

Participants

3

Reactant 1

HCID 67442054HCID 67442054, compound

Product 1

HCID 67441460HCID 67441460, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A mixture of methyl 3,3-dimethyl-2-(3-(pyrrolidin-1-ylsulfonyl)phenyl)-3,4-dihydroquinoline-6-carboxylate (140 mg, 0.328 mmol) in methanol/tetrahydrofuran (6 mL/6 mL) was treated with H2 at room temperature overnight. C-MS showed the reaction was complete. The mixture was separated by filtration and the filtrate was concentrate in vacuo to give 110.9 mg of methyl 3,3-dimethyl-2-(3-(pyrrolidin-1-ylsulfonyl)phenyl)-1,2,3,4-tetrahydroquinoline-6-carboxylate, yield: 78.9%.

Workup

  1. additionwas treated with H2 at room temperature overnight
  2. customThe mixture was separated by filtration
  3. concentrationthe filtrate was concentrate in vacuo

Sources & evidence

ORD record
ord-758bfe048f024a708377796c46de7b6d
Source dataset
uspto-grants-2013_01
Patent number
US08344137B2

Reaction notes

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