Dimethylformamide → HCID 86668497, compound

Participants

Reaction Conditions

Reaction Steps

Dichloropyrazine (100 mg, 0.454 mmol), 3-(3-methylphenyl)piperidine hydrochloride (85 mg, 0.454 mmol), and K2CO3 (157 mg, 1.136 mmol) were combined in a 25-mL round bottom flask with a stirbar. DMF (4.48 mL) was added, and the reaction mixture was heated to 50° C. for 4 h. The reaction mixture was diluted with EtOAc (20 mL), and washed sequentially with sat. aq. NaHCO3 (20 mL) and brine (20 mL). The combined organics were dried over MgSO4, filtered, and concentrated in vacuo to afford the title compound as a brown gum (155 mg, 76%), which was used in the subsequent step without further purification. Data for H-1: LC/MS: rt=3.17 min, m/z (M+H)=288.15 found; 288.79 required.

Provenance & Evidence