6-amino-3,4-dihydro-2H-1,4-benzothiazin-3-one → HCID 67333128, compound

Participants

Reaction Steps

A mixture of tert-butyl-dimethyl-((R)-3-oxiranyl-propoxy)-silane (13 g, 60 mmol, prepared according to Org. Lett. 2005, 7, 3997) and 6-amino-4H-benzo[1,4]thiazin-3-one (10.8 g) in EtOH/H2O (9:1, 325 mL) was heated at reflux overnight. The volatiles were removed under reduced pressure and the residue purified by CC (Hept/EA 1:1) to give the desired intermediate (6.8 g, 28% yield) as a brown oil.

Provenance & Evidence