HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methoxy-3-nitropyridine → HCID 68631941, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methoxy-3-nitropyridine | HCID 2795029 | — |
| Reactant | (3-Amino-2-hydroxy-propyl)-carbamic acid tert-butyl ester | HCID 86639750 | — |
| Product | HCID 68631941 | HCID 68631941 | 86% |
Reaction Steps
Starting from 2-chloro-6-methoxy-3-nitropyridine (5.4 g; commercial) and ((S)-3-amino-2-hydroxy-propyl)-carbamic acid tert-butyl ester (5.3 g, 1 eq.; prepared according to Adv. Synth. Catal. 2004, 346, 1195) and proceeding in analogy to Example 17, step 17.i, the title compound was obtained as a yellow solid (8.20 g; 86% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349826B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-488459f5b77149dcb762f902d097d189 |
| Source note | uspto-grants-2013_01 |