Potassium Carbonate → HCID 68630938, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 8-(bromomethyl)-2-methoxy-quinoxaline (8.0 g; prepared according to WO 2008/078305) and K2CO3 (8.74 g) in dioxane (154 mL) and water (20 mL) was degassed by bubbling N2 through for 20 min and treated with Pd(dppf)Cl2.DCM complex (1:1) (521 mg) and vinylboronic anhydride pyridine complex (5.12 g). The reaction was further stirred at 110° C. for 2 days and partitioned between water and ether. The org. phase was washed with water and brine, dried over MgSO4, concentrated under reduced pressure and purified by CC (Hex/EA 9:1 to 4:1), affording a yellow liquid (4.70 g, 74% yield).

Provenance & Evidence