Nitric Acid → 2-Nitro-4-n-butoxy-5-methoxybenzonitrile

Participants

Reaction Conditions

Reaction Steps

3-methoxy-4-n-butoxybenzonitrile (1.282 g, 6 mmol) and nitric acid (6 mL) were added into a round bottom flask, heated to 30° C. to react for 2 h, poured into ice-water; after complete stirring, the solution was filtered, washed with water and air-dried to yield 1.495 g of light yellow solid product with a recovery rate of 96%.

Provenance & Evidence