反应详情

温度

40 °C

2-nitro-4-butoxy-5-methoxybenzonitrile (0.563 g, 2.24 mmol), Pd/C (0.035 g) and anhydrous ethanol (25.0 mL) were added into a round bottom flask. The solution was stirred and heated under reflux. Cyclohexene (1.15 mL) was added and refluxed until the disappearance of the starting materials as monitored by TLC. After cooling, the resulting mixture was filtered and washed with ethanol. The filtrate was concentrated to yield a solid product. The crude product was suspended in anhydrous ethanol (4 ml), stirred and heated to 40° C. to react for 30 min, then cooled to room temperature, filtered and air-dried to yield 0.352 g of light yellow solid product with a recovery rate of 71%.

1. temperatureheated
2. temperatureunder reflux
3. temperaturerefluxed until the disappearance of the starting materials
4. temperatureAfter cooling
5. filtrationthe resulting mixture was filtered
6. washwashed with ethanol
7. concentrationThe filtrate was concentrated
8. customto yield a solid product
9. stirringstirred
10. customto react for 30 min
11. temperaturecooled to room temperature
12. filtrationfiltered
13. customair-dried