HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 1-Methyl-3-pyrrolidinaMine 2HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | tert-Butyl (1-methylpyrrolidin-3-yl)carbamate | HCID 23544388 | — |
| Product | 1-Methyl-3-pyrrolidinaMine 2HCl | HCID 45792254 | — |
Reaction Steps
The prepared N-methyl-3-t-butoxycarbonylaminopyrrolidine (1.8 g, 8.9 mmoles) is dissolved in HCl/dioxane (4N, 44 mL, 256 mmoles) and allowed to stir at RT for 45 min. The dioxane is removed by concentration and N-methyl-3-aminopyrrolidine dihydrochloride salt is dried under high vacuum (1.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349839B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0ef90fe745574f97a4c1c9bd9b028c38 |
| Source note | uspto-grants-2013_01 |