HCID 59803202, compound → HCID 59803209, compound

Participants

Reaction Steps

To a solution of methyl 1-(2-chloro-5-(hydroxymethyl)phenyl)piperidine-4-carboxylate 67 (0.198 g, 0.698 mmol) in DCM (3.5 mL) was added MnO2 (0.688 mg, 7.91 mmol). The reaction mixture was stirred at room temperature for 17 h, filtered, and concentrated in vacuo. Purification by flash column chromatography on silica gel (eluted with 10% to 40% EtOAc in hexanes) gave methyl 1-(2-chloro-5-formylphenyl)piperidine-4-carboxylate 68 (0.150 g, 76.3% yield) as a colorless oil. Mass spectrum: calculated for C14H16ClNO3 281.1. found 282.1 (M++1).

Provenance & Evidence