Sodium Methoxide → HCID 12073753, compound

HRID 1801624Notes

Reaction equation

HRID 1801624 reaction equation
Cl[C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[N:5]=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[N:3]=1.[CH3:15][O-:16].[Na+]>CO>[CH3:15][O:16][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[N:5]=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[N:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 21927804HCID 21927804, compound

Product 1

HCID 12073753HCID 12073753, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

18.05 g (90 mmol) of 4-chloro-2-methylsulfonyl-6,7-dihydro-5H-cyclopentapyrimidine were dissolved in 200 ml of methanol. At 45° C., 16.7 g of sodium methoxide (as 30% strength solutions in methanol) were added dropwise, and the mixture was stirred for 2 hours. The solution was evaporated, taken up in ethyl acetate and acidified with dilute hydrochloric acid, and the ethyl acetate extract was evaporated. 15.5 g of an oil remained.

Workup

  1. customThe solution was evaporated
  2. extractionthe ethyl acetate extract
  3. customwas evaporated

Sources & evidence

ORD record
ord-27a9a417e1344e8bb72d49536be7b688
Source dataset
uspto-grants-2013_01
Patent number
US08349843B2

Reaction notes

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