HCID 11978936, compound → HCID 66886276, compound

HRID 1801648Notes

Reaction equation

HRID 1801648 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:29]=[C:28]5[C:23]([CH2:24][CH2:25][N:26]([CH3:31])[C:27]5=[O:30])=[CH:22][CH:21]=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.C(O)C.[ClH:35]>C(O)C>[ClH:35].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:29]=[C:28]5[C:23]([CH2:24][CH2:25][N:26]([CH3:31])[C:27]5=[O:30])=[CH:22][CH:21]=4)[CH2:14][CH2:15]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

4

Reactant 2

HCID 11978936HCID 11978936, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 66886276HCID 66886276, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one was made into an ethanol solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from ethanol and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-074a096ee5384c8592d12b56bbf844b5
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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