HCID 11978937, compound → HCID 86643435, compound

HRID 1801650Notes

Reaction equation

HRID 1801650 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][O:20]C4C=C5C(CCN(C)C5=O)=CC=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:33]CCCCO[C:39]1[CH:48]=[C:47]2[C:42]([CH2:43][CH2:44][N:45]([CH3:50])[C:46]2=[O:49])=[CH:41][CH:40]=1.CO.Cl>CO>[ClH:33].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH:44]4[CH2:43][C:42]5[C:47](=[CH:48][CH:39]=[CH:40][CH:41]=5)[C:46](=[O:49])[N:45]4[CH3:50])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 11978937HCID 11978937, compoundHCID 21893726Hydrochloride methanolHCID 66885306HCID 66885306, compound

Product 1

HCID 86643435HCID 86643435, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

By a similar method as in Example 1, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one was prepared from 7-(4-chlorobutoxy)-2-methyl-3,4-dihydro-2H-isoquinolin-1-one, and after it was made into a methanol solution, 0.5N hydrochloric acid methanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from a mixed solvent of methanol-ethyl acetate and thereby 7-[(4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from a mixed solvent of methanol-ethyl acetate

Sources & evidence

ORD record
ord-457e2fe23ec046349b7ef3f2472e3246
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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