Sulfuric Acid → 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one sulfate

HRID 1801658Notes

Reaction equation

HRID 1801658 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[S:6]1[CH:10]=[CH:9][C:8]2[C:11]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:26]4[CH:35]=[C:34]5[C:29]([CH:30]=[CH:31][C:32](=[O:36])[NH:33]5)=[CH:28][CH:27]=4)[CH2:17][CH2:16]3)=[CH:12][CH:13]=[CH:14][C:7]1=2>CO.ClCCl>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[S:6]1[CH:10]=[CH:9][C:8]2[C:11]([N:15]3[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:26]4[CH:35]=[C:34]5[C:29]([CH:30]=[CH:31][C:32](=[O:36])[NH:33]5)=[CH:28][CH:27]=4)[CH2:19][CH2:20]3)=[CH:12][CH:13]=[CH:14][C:7]1=2

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 11978813Brexpiprazole

Product 1

HCID 668858127-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one sulfate

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

Dilute sulphuric acid was added to a solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from 60% ethanol and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one sulfate was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 60% ethanol

Sources & evidence

ORD record
ord-bb38a68032584497b68f035664d55a38
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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