Maleic Acid → 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one maleate

HRID 1801659Notes

Reaction equation

HRID 1801659 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][C:29]4[CH:38]=[C:37]5[C:32]([CH:33]=[CH:34][C:35](=[O:39])[NH:36]5)=[CH:31][CH:30]=4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=[CH:17][C:10]1=2>CO.ClCCl>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][C:29]4[CH:38]=[C:37]5[C:32]([CH:33]=[CH:34][C:35](=[O:39])[NH:36]5)=[CH:31][CH:30]=4)[CH2:22][CH2:23]3)=[CH:15][CH:16]=[CH:17][C:10]1=2

Participants

5

Reactant 2

HCID 444266Maleic AcidHCID 11978813Brexpiprazole

Product 1

HCID 668862997-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one maleate

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 6344DichloromethaneSolvent

Procedure

A methanol solution of maleic acid was added to a solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from 80% ethanol and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one maleate was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 80% ethanol

Sources & evidence

ORD record
ord-cfbd97e14d434734b958f767bea8aa63
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

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