Sulfuric Acid → HCID 66885854, compound

HRID 1801663Notes

Reaction equation

HRID 1801663 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[S:6]1[CH:10]=[CH:9][C:8]2[C:11]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:34]=[C:33]5[C:28]([CH2:29][CH2:30][N:31]([CH3:36])[C:32]5=[O:35])=[CH:27][CH:26]=4)[CH2:17][CH2:16]3)=[CH:12][CH:13]=[CH:14][C:7]1=2>C(O)C.ClCCl>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[S:6]1[CH:10]=[CH:9][C:8]2[C:11]([N:15]3[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:34]=[C:33]5[C:28]([CH2:29][CH2:30][N:31]([CH3:36])[C:32]5=[O:35])=[CH:27][CH:26]=4)[CH2:19][CH2:20]3)=[CH:12][CH:13]=[CH:14][C:7]1=2

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 11978936HCID 11978936, compound

Product 1

HCID 66885854HCID 66885854, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

Dilute sulphuric acid was added to a solution of 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one in ethanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from 85% ethanol and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one sulfate was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 85% ethanol

Sources & evidence

ORD record
ord-089e2650b44c42c58d0df67811499410
Source dataset
uspto-grants-2013_01
Patent number
US08349840B2

Reaction notes

Loading…