2-Thiophenecarboxaldehyde → HCID 67547935, compound

Participants

Reaction Steps

The title compound was prepared from 3-bromo-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (500 mg, 2.091 mmol) and thiophene-2-carboxaldehyde (351 mg, 3.129 mmol) in the presence of sodium ethoxide (284 mg, 4.175 mmol) in absolute ethanol (25 ml) as described in Intermediate 1 to give 283 mg of the product as a light yellow solid; 1H NMR (300 MHz, CDCl3) δ 7.06 (s, 2H), 7.31-7.43 (m, 3H), 7.63 (dd, J=2.4, 16.2 Hz, 2H), 8.15 (d, J=14.7 Hz, 1H), 8.94 (d, J=6.9 Hz, 1H).

Provenance & Evidence