3-bromo-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one → HCID 67547242, compound

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Reaction Steps

The title compound was prepared from 3-bromo-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (500 mg, 2.091 mmol) and 2-(cyclopentyloxy)-3-methoxybenzaldehyde (514 mg, 2.503 mmol) in the presence of sodium ethoxide (213 mg, 3.131 mmol) in absolute ethanol (15 ml) as described in Intermediate 1 to give 383 mg of the product as a light yellow solid; 1H NMR (CDCl3) δ 1.61-1.69 (m, 4H), 1.70-1.79 (m, 4H), 2.33 (s, 3H), 4.51 (br s, 1H), 7.01-7.07 (m, 2H), 7.12-7.24 (m, 1H), 7.57-7.60 (m, 4H), 8.43 (d, J=15.6 Hz, 1H), 8.94 (d, J=6.3 Hz, 1H).

Provenance & Evidence