3-bromo-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one → HCID 67547673, compound

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Reaction Steps

The title compound was prepared from 3-bromo-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (1.0 g, 4.181 mmol) and 2-(cyclopropylmethoxy)-3-methoxybenzaldehyde (1.29 g, 6.255 mmol) in the presence of sodium ethoxide (0.56 g, 8.361 mmol) in absolute ethanol (30 ml) as described in Intermediate 1 to give 424 mg of the product as a light yellow solid; 1H NMR (300 MHz, CDCl3) δ 0.35-0.40 (m, 2H), 0.60-0.79 (m, 2H), 1.30-1.40 (m, 1H), 3.82-3.90 (m, 5H), 6.90 (d, J=7.8 Hz, 1H), 7.04-7.12 (m, 2H), 7.33 (d, J=7.8 Hz, 1H), 7.62-7.72 (m, 3H), 8.48 (d, J=15.6 Hz, 1H), 8.95 (d, J=7.5 Hz, 1H).

Provenance & Evidence