HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Hydroxy-7-trifluoromethyl-3-(chloromethyl)-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178519811 | HCID 178519811 | — |
| Product | 4-Hydroxy-7-trifluoromethyl-3-(chloromethyl)-quinoline | HCID 178516189 | 82.6% |
Reaction Steps
4-Hydroxy-7-trifluoromethyl-3-(hydroxymethyl)-quinoline (3.6 grams) was added to an excess (5.9 grams) of thionyl chloride and the mixture was refluxed for 1 hour. Excess thionyl chloride was then evaporated and the remaining residue was crystallized from hexane to give 4-hydroxy-7-trifluoromethyl-3-(chloromethyl)-quinoline (3.2 grams).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349850B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-54b2059001a4403289244cee036e6bc4 |
| Source note | uspto-grants-2013_01 |