HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-thiopseudourea → HCID 178418413, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-thiopseudourea | HCID 5142 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178418413 | HCID 178418413 | 65% |
Reaction Steps
2-Methyl-2-thiopseudourea (5 mmol) and ethyl ethoxymethylenecyanoacetate (5 mmol) were dissolved in 20 ml EtOH. To this was added K2CO3 (10 mmol). After the mixture was refluxed for 48 h, it was cooled to room temperature and filtered. The solvent was concentrated in vacuo and purified by column chromatography to give 4-hydroxy-2-(methylthio) pyrimidine-5-carbonitrile in a yield of 65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349859B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-852e624b049a43a1941c99032e43ac91 |
| Source note | uspto-grants-2013_01 |