4-Chlorophenylboronic acid → HCID 58067820, compound

HRID 1801764Notes

Reaction equation

HRID 1801764 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](Br)=[CH:4][N:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([C:5]2[CH:6]=[C:7]([CH3:8])[C:2]([NH2:1])=[N:3][CH:4]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 1379342-Amino-5-bromo-3-methylpyridine

Product 1

HCID 58067820HCID 58067820, compoundYield 83%

Procedure

Prepared as described in example C.32 (step 4) from commercially available 2-amino-5-bromo-3-methyl-pyridine (4 g, 21.4 mmol) and commercially available 4-chlorophenylboronic acid (3.68 g, 23.5 mmol). Obtained as an off-white solid (3.86 g, 83%). MS (EI) 218.1 [(M)+]; mp 156° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-01a8f913ab744a1780fd20525187ff18
Source dataset
uspto-grants-2013_01
Patent number
US08349844B2

Reaction notes

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