HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromo-3-methylpyridine → 3-Methyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromo-3-methylpyridine | HCID 137934 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Product | 3-Methyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-ylamine | HCID 66650570 | 88.2% |
Reaction Steps
Prepared as described in example C.32 (step 4) from commercially available 2-amino-5-bromo-3-methyl-pyridine (4.5 g, 24.1 mmol) and commercially available 4-trifluoromethyl-phenylboronic acid (5.03 g, 26.5 mmol). Obtained as an off-white solid (5.36 g, 88%). MS (ISP) 252.9 [(M+H)+]; mp 159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349844B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0b1d14ff22d9458dbb0dc950c77f766e |
| Source note | uspto-grants-2013_01 |