2-Amino-5-bromopyridine → HCID 20099814, compound

HRID 1801766Notes

Reaction equation

HRID 1801766 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][N:3]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][C:14]([C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[N:3][CH:4]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 20099814HCID 20099814, compoundYield 71%

Procedure

Prepared as described in example C.32 (step 4) from commercially available 2-amino-5-bromo-pyridine (3.46 g, 20.0 mmol) and commercially available 4-trifluoromethyl-phenylboronic acid (4.18 g, 22.0 mmol). Obtained as an off-white solid (3.36 g, 71%). Mp 130° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-02dde10b1ef3462c904bb00e1adbbcc6
Source dataset
uspto-grants-2013_01
Patent number
US08349844B2

Reaction notes

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