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HRID1801771

反应详情

EQUATION

反应方程式

HRID 1801771 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12
HCID66650268

未命名化合物

结构：N=C(NO)c1cccc(S(N)(=O)=O)c1
HCID178513322

未命名化合物

PRODUCTS

生成物

1
结构：NS(=O)(=O)c1cccc(-c2noc(-c3cnn4c(C(F)F)cc(-c5ccc(C(F)(F)F)cc5)nc34)n2)c1
HCID16068666

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) (179 mg, 0.5 mmol) and N-hydroxy-3-sulfamoyl-benzamidine [CAS-No. 9000-88-7] (161 mg, 0.75 mmol) according to general procedure II. Obtained after purification by column chromatography (dichloromethane/MeOH/NH4OH) and crystallization (ethyl acetate/hexane) as a yellow solid (198 mg, 74%). MS (ISN) 535.3 [(M−H)−]; mp 267° C.

WORKUP

后处理

  1. customObtained
  2. customafter purification
  3. customby column chromatography (dichloromethane/MeOH/NH4OH) and crystallization (ethyl acetate/hexane) as a yellow solid (198 mg, 74%)