2,3-Dichloro-5-nitropyridine → 1-(3-(3-Chloro-5-nitropyridin-2-yloxy)phenyl)-4-methylpiperazine

HRID 1801854Notes

Reaction equation

HRID 1801854 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=2)[CH2:4][CH2:3]1.Cl[C:16]1[C:21]([Cl:22])=[CH:20][C:19]([N+:23]([O-:25])=[O:24])=[CH:18][N:17]=1>>[Cl:22][C:21]1[C:16]([O:14][C:10]2[CH:9]=[C:8]([N:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]3)[CH:13]=[CH:12][CH:11]=2)=[N:17][CH:18]=[C:19]([N+:23]([O-:25])=[O:24])[CH:20]=1

Participants

3

Reactant 2

HCID 27631062,3-Dichloro-5-nitropyridineHCID 110114553-(4-Methylpiperazin-1-yl)phenol

Product 1

HCID 668863411-(3-(3-Chloro-5-nitropyridin-2-yloxy)phenyl)-4-methylpiperazine

Procedure

3-(4-Methylpiperazin-1-yl)phenol was reacted with 2,3-dichloro-5-nitro pyridine (as obtained in preparation 1), to obtain 1-(3-(3-chloro-5-nitropyridin-2-yloxy)phenyl)-4-methylpiperazine which was further converted to the title compound as per the procedure described in preparation 2.

Sources & evidence

ORD record
ord-43c8546b28014a38beb553bfdfe93fab
Source dataset
uspto-grants-2013_01
Patent number
US08349862B2

Reaction notes

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