HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(3-fluorobenzyloxy)aniline → HCID 68751757, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(3-fluorobenzyloxy)aniline | HCID 7059263 | — |
| Reactant | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68751757 | HCID 68751757 | 100.1% |
Reaction Steps
In 180 ml of tetrahydrofuran were dissolved 4-chloro-6-iodoquinazoline (6.0 g) and 3-chloro-4-(3-fluorobenzyloxy)aniline (II-1, 5.2 g), followed by heat refluxing for 3 hours. A precipitate was filtered, and washed with tetrahydrofuran to obtain 4-(4-(3-fluorobenzyloxy)phenylamino)-6-iodoquinazoline hydrochloride (III-1, 10.5 g) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349857B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-98a3838313784d1fbaa27549038f4e7c |
| Source note | uspto-grants-2013_01 |