HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline → 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline | HCID 72942927 | — |
| Reactant | HCID 178422977 | HCID 178422977 | — |
| Reactant | HCID 178487748 | HCID 178487748 | — |
| Product | 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline | HCID 86649057 | — |
Reaction Steps
4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline was obtained according to the procedure described in Example 26 for synthesis of 4-chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline, substituting 2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazolin-4-ol in Example 26 with 2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazolin-4-ol. 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methoxyquinazoline was isolated as a light yellow solid (0.290 g, 89%). LC-MS (ESI) m/z 339 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08349851B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-abdcb8f1977946a0ae35f6567abab7f5 |
| Source note | uspto-grants-2013_01 |