HCID 178493080, compound → HCID 178493081, compound

HRID 1801966Notes

Reaction equation

HRID 1801966 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:19]=[C:18]([NH:20][C:21]3[CH:25]=[C:24]([O:26][CH3:27])[NH:23][N:22]=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[O:9])=[CH:4][CH:3]=1.N1C=CC(NC2C3C(=CC=CC=3)N=C(C(C3C=CC(F)=CC=3)=O)N=2)=N1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[N:19]=[C:18]([NH:20][C:21]3[CH:25]=[C:24]([O:26][CH3:27])[NH:23][N:22]=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[OH:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 178493080HCID 178493080, compoundHCID 178519621HCID 178519621, compound

Product 1

HCID 178493081HCID 178493081, compound

Procedure

(4-Fluorophenyl)(4-(5-methoxy-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanol is prepared using a procedure analogous to that described in Example 6, substituting (4-fluorophenyl)(4-(5-methoxy-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone from Example 75 for the (4-(1H-pyrazol-3-ylamino)quinazolin-2-yl)(4-fluorophenyl)methanone used in Example 6.

Sources & evidence

ORD record
ord-3f25251b312f48b0a7d8c83d957464d2
Source dataset
uspto-grants-2013_01
Patent number
US08349851B2

Reaction notes

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