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HRID 1801986作成日：2026年10月25日
2-Ethylpropanedioyl dichloride → Ethyl 4-hydroxy-1-methyl-2-oxo-7-(trifluoromethyl)-1,2-dihydro-1,8-naphthyridine-3-carboxylate
https://huagongshe.com/reaction/1801986
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Ethylpropanedioyl dichloride | HCID 10920924 | — |
| 反応物 | Methyl 2-(methylamino)-6-(trifluoromethyl)nicotinate | HCID 57671595 | — |
| 反応物 | Methyl 2-(3-ethoxy-N-methyl-3-oxopropanamido)-6-(trifluoromethyl)nicotinate | HCID 57671654 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Ethyl 4-hydroxy-1-methyl-2-oxo-7-(trifluoromethyl)-1,2-dihydro-1,8-naphthyridine-3-carboxylate | HCID 57671568 | — |
反応手順
Methyl 2-(3-ethoxy-N-methyl-3-oxopropanamido)-6-(trifluoromethyl)nicotinate. A mixture of methyl 2-(methylamino)-6-(trifluoromethyl)nicotinate (0.300 g) and ethyl malonoyl chloride (0.19 mL, 1.6 mmol) in 1,2-dichloroethane (50 mL) was heated to 80° C. for 63 hours. The reaction mixture was allowed to reach room temperature and was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (gradient: 0-30% EtOAc/hexanes) to give the title compound. MS (ESI, pos. ion) m/z: 349 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08349868B2 |
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| 出典データセット | uspto-grants-2013_01 |
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| ORD ID | ord-6d147c0ed63041f3bbd432cdfb0da141 |
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| 出典メモ | uspto-grants-2013_01 |
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