Butanoic acid, 4-chloro-4-oxo-, ethyl ester → HCID 57742976, compound

HRID 1801997Notes

Reaction equation

HRID 1801997 reaction equation
C(OCC)(=O)CCC([O:6][C:7]1[C:16]2[CH:15]=[C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:13]=[N:12][C:11]=2[N:10]([CH3:23])[C:9](=[O:24])[CH:8]=1)=O.OC1C2C=C(C3C=CC=CC=3)N=NC=2N(C)C(=O)C=1.Cl[C:49](=[O:57])[CH2:50][CH2:51][C:52]([O:54]CC)=[O:53]>>[OH:6][C:7]1[C:16]2[CH:15]=[C:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:13]=[N:12][C:11]=2[N:10]([CH3:23])[C:9](=[O:24])[C:8]=1[C:49](=[O:57])[CH2:50][CH2:51][C:52]([OH:54])=[O:53]

Participants

4

Reactant 3

HCID 84648Butanoic acid, 4-chloro-4-oxo-, ethyl esterHCID 67406203HCID 67406203, compoundHCID 67407440HCID 67407440, compound

Product 1

HCID 57742976HCID 57742976, compound

Procedure

Ethyl 8-methyl-7-oxo-3-phenyl-7,8-dihydropyrido[2,3-c]pyridazin-5-yl succinate. The title compound is prepared by acylation of 5-hydroxy-8-methyl-3-phenylpyrido[2,3-c]pyridazin-7(8H)-one with ethyl 4-chloro-4-oxobutanoate according to that described in Method 4 (step b).

Sources & evidence

ORD record
ord-d9582eea59114940b1a3fe3aa5704ffe
Source dataset
uspto-grants-2013_01
Patent number
US08349868B2

Reaction notes

Loading…