Sodium Acetate → HCID 57742976, compound

HRID 1801998Notes

Reaction equation

HRID 1801998 reaction equation
[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:8]=[N:7][C:6]=2[N:5]([CH3:18])[C:4](=[O:19])[C:3]=1[C:20](=[O:28])[CH2:21][CH2:22][C:23]([O:25]CC)=[O:24].C(OCC)(=O)CCC(OC1C2C=C(C3C=CC=CC=3)N=NC=2N(C)C(=O)C=1)=O.C([O-])(=O)C.[Na+].[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:8]=[N:7][C:6]=2[N:5]([CH3:18])[C:4](=[O:19])[C:3]=1[C:20](=[O:28])[CH2:21][CH2:22][C:23]([OH:25])=[O:24]

Participants

5

Reactant 4

HCID 517045Sodium AcetateHCID 6451240Aluminum(III) ChlorideHCID 67406664HCID 67406664, compoundHCID 67407440HCID 67407440, compound2×

Product 1

HCID 57742976HCID 57742976, compound

Procedure

Ethyl 4-(5-hydroxy-8-methyl-7-oxo-3-phenyl-7,8-dihydropyrido[2,3-c]pyridazin-6-yl)-4-oxobutanoate. The title compounds is prepared by rearrangement of ethyl 8-methyl-7-oxo-3-phenyl-7,8-dihydropyrido[2,3-c]pyridazin-5-yl succinate using sodium acetate according to literature procedures. Alternatively, the title compound is prepared by rearrangement of ethyl 8-methyl-7-oxo-3-phenyl-7,8-dihydropyrido[2,3-c]pyridazin-5-yl succinate using aluminum chloride according to that described in Method 4 (step c).

Sources & evidence

ORD record
ord-1217f1a73f874c2b9186f885bb1b09d4
Source dataset
uspto-grants-2013_01
Patent number
US08349868B2

Reaction notes

Loading…