Isopropylamine → HCID 57377523, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-methyl-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid (100 mg, 276 μmol), isopropylamine (119 μl, 1.38 mmol) and propylphosphonic anhydride (50% in ethyl acetate, 407 ul, 318.8 mmol) in tetrahydrofurane (7.00 ml) is stirred for 20 hours at 70° C. under nitrogen atmosphere. The solvent is evaporated and to the residue is added sat. aqueous sodium hydrogencarbonate solution. The mixture is stirred for 20 minutes while a white solid precipitates. The solid is collected by filtration, washed with diethylether and dried affording N4-isopropyl-1-methyl-N5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-4,5-dicarboxamide (93 mg, 83.8%) as a white solid. mp.: >250° C. MS: m/z=404.4 (M+H+).

Provenance & Evidence