Hydrochloric Acid → 1-methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

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Reaction Conditions

Reaction Steps

A mixture of methyl 1-methyl-5-(2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylate (560 mg, 1.48 mmol) and lithium hydroxide monohydrate (125 mg, 2.97 mmol) in methanol (10 ml) and water (3 ml) is stirred for 18 hours at 50° C. The methanol is evaporated and the resulting suspension treated with 2N aqueous hydrochloric acid (1.485 ml, 2.97 mmol) The solvent is evaporated affording 1-methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid containing 2 equivalents lithium chloride (670 mg, 101%). mp.: >250° C. MS: m/z=362.0 (M+H+).

Provenance & Evidence