Ethylamine hydrochloride → 7-{[4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carbonyl]-amino}-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylic acid ethylamide

Participants

Reaction Steps

The product was prepared in the same manner as described in example 62 using 7-(4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxamido)-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylic acid (130 mg, 264 μmol) and ethanamine hydrochloride (215 mg, 2.64 mmol) as starting materials. The reactions affords 7-{[4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carbonyl]-amino}-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylic acid ethylamide (38 mg, 36.3%) as a white solid. mp: 217-229° C., MS: m/z=397.1 (M+H+)

Provenance & Evidence