2-Methoxyethylamine → 7-(4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxamido)-N-(2-methoxyethyl)-[1,2,4]triazolo[1,5-a]pyridine-2-carboxamide

Participants

Reaction Steps

The product was prepared in the same manner as described in example 62 using 7-(4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxamido)-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylic acid (140 mg, 0.379 mmole) and 2-methoxyethanamine (163 l, 1.9 mmole) as starting materials. The reactions affords 7-(4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxamido)-N-(2-methoxyethyl)-[1,2,4]triazolo[1,5-a]pyridine-2-carboxamide (32 mg, 19.8%) as a white solid. mp: 159-161° C., MS: m/z=427.3 (M+H+).

Provenance & Evidence