Lithium hydroxide, monohydrate → 5-(2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid

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Reaction Conditions

Reaction Steps

A mixture of ethyl 5-(2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylate (1.2 g, 3.05 mmol) and lithium hydroxide hydrate (512 mg, 12.2 mmol) in methanol (40 ml) and water (10 ml) was stirred for 4 hours at 50° C. The solvent was evaporated, the residue was dissolved with water and acidified to pH=0 using hydrochloric acid 37%. The precipitated solid was filtered off and washed with water and dried in vacuo affording 5-(2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid (929 mg, 83.4%) as a light brown solid. mp: >250° C., MS: m/z=362.7/364.8 (M+H+)

Provenance & Evidence