2-Methoxyphenylboronic acid → HCID 57378390, compound

Participants

Reaction Steps

The product was prepared in the same manner as described in example 66 using N-(2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1-methyl-4-(morpholine-4-carbonyl)-1H-pyrazole-5-carboxamide (200 mg, 461 μmol) and 2-methoxyphenylboronic acid (140 mg, 921 μmol) as starting materials. The crude material was applied on silicagel and purified by flash chromatography over a 20 g silicagel column using ethyl acetate/methanol 10% as eluent affording 2-methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(2-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-amide (109 mg, 51.3%) as a light brown foam. MS: m/z=462.5 (M+H+).

Provenance & Evidence