Morpholine → 2-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-amide

HRID 1802266Notes

Reaction equation

HRID 1802266 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:29]=[C:12]3[CH:13]=[C:14]([NH:17][C:18]([C:20]4[N:24]([CH3:25])[N:23]=[CH:22][C:21]=4[C:26](O)=[O:27])=[O:19])[CH:15]=[CH:16][N:11]3[N:10]=2)[CH:6]=[CH:7][CH:8]=1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:29]=[C:12]3[CH:13]=[C:14]([NH:17][C:18]([C:20]4[N:24]([CH3:25])[N:23]=[CH:22][C:21]=4[C:26]([N:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)=[O:27])=[O:19])[CH:15]=[CH:16][N:11]3[N:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 677739945-[2-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 573784952-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-amide

Procedure

This compound was prepared in the same manner as described in example 75 starting from 5-[2-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid (Example 75, step e) (1.0 g, 2.55 mmol) and morpholine (245 ul, 2.80 mmol). Off-white solid (937 mg, 80%). LC-MS: m/z=462.6 [M+H]+.

Workup

  1. customThis compound was prepared in the same manner

Sources & evidence

ORD record
ord-f5e26a9ab2f546e8ae134fb108c6c5c9
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

Loading…