Fluoromethyl 4-methylbenzenesulfonate → HCID 57378613, compound

HRID 1802269Notes

Reaction equation

HRID 1802269 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:33]=[C:11]3[CH:12]=[C:13]([NH:16][C:17]([C:19]4[N:20]([CH3:32])[N:21]=[CH:22][C:23]=4[C:24]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[O:25])=[O:18])[CH:14]=[CH:15][N:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[F:34][CH2:35]OS(C1C=CC(C)=CC=1)(=O)=O>>[F:34][CH2:35][O:1][C:2]1[CH:3]=[C:4]([C:8]2[N:33]=[C:11]3[CH:12]=[C:13]([NH:16][C:17]([C:19]4[N:20]([CH3:32])[N:21]=[CH:22][C:23]=4[C:24]([N:26]4[CH2:27][CH2:28][O:29][CH2:30][CH2:31]4)=[O:25])=[O:18])[CH:14]=[CH:15][N:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 13862289Fluoromethyl 4-methylbenzenesulfonateHCID 57378611HCID 57378611, compound

Product 1

HCID 57378613HCID 57378613, compound

Procedure

This compound was prepared in the same manner as described in example 81 starting from 2-methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(3-hydroxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-amide (Example 80) (250 mg, 0.559 mmol) and toluene-4-sulfonic acid fluoromethyl ester (171 mg, 0.838 mmol). White solid (10 mg, 4%). LC-MS: m/z=480.4 [M+H]+.

Workup

  1. customThis compound was prepared in the same manner

Sources & evidence

ORD record
ord-d422599abf1241df98e6fa3c7e47d98d
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

Loading…