Glycine, N-methyl-, methyl ester, hydrochloride (1:1) → {Methyl-[1-methyl-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carbonyl]-amino}-acetic acid methyl ester

Participants

Reaction Steps

This compound was prepared in the same manner as described in example 92 starting from 1-methyl-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carbonyl chloride (Example 92, step a) (263 mg, 691 μmol) and methyl 2-(methylamino)acetate hydrochloride (482 mg, 3.45 mmol). Additional TEA (349 mg, 481 μl) was added to the reaction mixture. The final product was isolated as white solid (146 mg, 46%); MS: m/z=448.2 [M+H]+.

Provenance & Evidence