3-Fluorobenzoyl chloride → 7-Bromo-2-(3-fluorophenyl)-[1,2,4]triazolo[1,5-A]pyridine

Participants

Reaction Steps

The product was prepared in the same manner as described in example 1b using 1,2-diamino-4-bromopyridinium 2,4,6-trimethylbenzenesulfonate (2 g, 5.15 mmol) and 3-fluorobenzoyl chloride (1.24 ml, 10.3 mmol) as starting materials. The reaction affords 7-Bromo-2-(3-fluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridine (1.067 g, 70.9%) as pink solid. mp.: 186-188° C., MS: m/z=291.9/293.9 (M+H+).

Provenance & Evidence