Thionyl Chloride → 2-Fluoropyridine-3-carbonyl chloride

Participants

Reaction Steps

A mixture of 2-fluoronicotinic acid (5.00 g, 35.4 mmol) and thionyl chloride (35 ml, 480 mmol) was refluxed for 48 hours. The thionyl chloride was distilled off at ambient pressure, the residue was distilled under high vacuum. The reaction affords 2-fluoronicotinoyl chloride (4.45 g, 78.7%) as white solid. MS: m/z=156.1 (M+H+).

Provenance & Evidence