tert-Butyl carbamate → [2-(2-Fluoro-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester

HRID 1802289Notes

Reaction equation

HRID 1802289 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]3[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=3)[N:10]=[C:4]2[CH:3]=1.[C:18](=[O:25])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[NH2:19]>>[C:21]([O:20][C:18](=[O:25])[NH:19][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[C:9]([C:11]3[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=3)[N:10]=[C:4]2[CH:3]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 677746577-Bromo-2-(2-fluoropyridin-3-YL)-[1,2,4]triazolo[1,5-A]pyridine

Product 1

HCID 67776667[2-(2-Fluoro-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl esterYield 70.4%

Procedure

The product was prepared in the same manner as described in example 1c using 7-bromo-2-(2-fluoropyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine (1.1 g, 3.75 mmol) and tert-butyl carbamate (528 mg, 4.5 mmol) as starting materials. The reaction affords [2-(2-fluoro-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-carbamic acid tert-butyl ester (870 mg, 70.4%), as light yellow solid. MS: m/z=330.1 (M+H+).

Workup

  1. customThe product was prepared in the same manner

Sources & evidence

ORD record
ord-f776d38ad18a4dfc9bb1ef4cb928c7cb
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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