4-(Ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid → 5-[2-(2-fluoro-pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Participants

Reaction Steps

The product was prepared in the same manner as described in example 44d using 2-(2-fluoropyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-amine (0.5 g, 2.18 mmol) and 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (519 mg, 2.62 mmol) as starting materials. The reaction affords 5-[2-(2-fluoro-pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (585 mg, 65.5%) as white solid. mp.: 220-230° C., MS: m/z=410.0 (M+H+).

Provenance & Evidence