2-Fluoro-6-pyridinecarbonyl chloride → HCID 67774331, compound

HRID 1802300Notes

Reaction equation

HRID 1802300 reaction equation
CC1C=C(C)C=C(C)C=1S([O-])(=O)=O.[NH2:14][N+:15]1[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][C:16]=1[NH2:22].[F:23][C:24]1[N:29]=[C:28]([C:30](Cl)=O)[CH:27]=[CH:26][CH:25]=1>>[Br:21][C:18]1[CH:19]=[CH:20][N:15]2[N:14]=[C:30]([C:28]3[CH:27]=[CH:26][CH:25]=[C:24]([F:23])[N:29]=3)[N:22]=[C:16]2[CH:17]=1

Participants

3

Reactant 2

HCID 27591602-Fluoro-6-pyridinecarbonyl chlorideHCID 866660161,2-Diamino-4-bromo-pyridinium 2,4,6-trimethyl-benzenesulfonate

Product 1

HCID 67774331HCID 67774331, compoundYield 85.4%

Procedure

The product was prepared in the same manner as described in example 1b using 1,2-diamino-4-bromopyridinium 2,4,6-trimethylbenzenesulfonate (2.24 g, 5.77 mmol) and 6-fluoropicolinoyl chloride (1.84 g, 11.5 mmol) as starting materials. The reaction affords 7-bromo-2-(6-fluoro-pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (1.44 g, 85.4%) as brown solid. MS: m/z=294.9 (M+H+).

Workup

  1. customThe product was prepared in the same manner

Sources & evidence

ORD record
ord-fd0767255f6c42e1a02ae073b21f7472
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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