N-Methylcyclopropanamine → HCID 67774606, compound

Participants

Reaction Steps

2,7-dibromo-[1,2,4]triazolo[1,5-a]pyridine (1.5 g, 5.42 mmol) was refluxed in N-methylcyclopropanamine (3.85 g, 54.2 mmol) for 4 h. The solvent was evaporated and the residue was diluted with ethyl acetate and washed with water and brine. The organic layer was dried over magnesium sulfate, filtered and applied on SiO2. Column chromatography over 70 g SiO2 using heptane/ethyl acetate affords (7-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-cyclopropyl-methyl-amine (593 mg, 41%) as white powder. MS: m/z=397.1 (M+H+).

Provenance & Evidence