HCID 19623797, compound → 2-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid

HRID 1802314Notes

Reaction equation

HRID 1802314 reaction equation
[CH3:1][N:2]([CH3:14])[C:3]([C:5]1[CH:9]=[N:8][N:7]([CH3:10])[C:6]=1[C:11]([OH:13])=[O:12])=[O:4].CN1C=C(C(N2C[CH2:27][O:26][CH2:25]C2)=O)C=N1>>[CH3:10][N:7]1[C:6]([C:11]([OH:13])=[O:12])=[C:5]([C:3]([N:2]2[CH2:14][CH2:27][O:26][CH2:25][CH2:1]2)=[O:4])[CH:9]=[N:8]1

Participants

3

Reactant 2

HCID 19623797HCID 19623797, compoundHCID 39969381(1-Methyl-1H-pyrazol-4-yl)-morpholin-4-yl-methanone

Product 1

HCID 196238122-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid

Procedure

This compound was prepared in analogy to 4-dimethylcarbamoyl-2-methyl-2H-pyrazole-3-carboxylic acid (Example 97, step b) from (1-methyl-1H-pyrazol-4-yl)-morpholin-4-yl-methanone (1.20 g, 6.15 mmol). Yield: 1.05 g (71%); off-white solid; MS: m/z=240.2 ([M+H]+)

Sources & evidence

ORD record
ord-a53258d9206e4a6b9885052bdbc653ea
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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