Methanol → methyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazoly)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboximidate

Participants

Reaction Steps

A solution of methyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboximidothioate (i.e. the product of Example 1, Step D) (0.10 g, 0.20 mmol) in methanol (5 mL) was heated in a Biotage® Creator XM microwave apparatus at 140° C. for 1.5 h. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel using 1:1 ethyl acetate-hexanes as eluant to provide the title compound, a compound of the present invention, as a foamy white solid (19 mg).

Provenance & Evidence