Ammonia → HCID 178425130, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperidinecarboximidoyl chloride (i.e. the product of Step B) (0.300 g, 0.63 mmol) in dichloromethane (4 mL) was added dropwise to a solution of ammonia in mathanol (7M, 10 ml) which was cooled to 0° C. The reaction mixture was stirred for 2 minutes, concentrated under reduced pressure, and the resulting tan solid portioned between dichloromethane and saturated aqueous sodium bicarbonate solution. The organic layer was dried and concentrated under reduced pressure to give of the title, a compound of the present invention, compound as a foamy white solid (0.25 g).

Provenance & Evidence